MRI Lumbar spine
Ligamentum Flavum Hypertrophy
Mechanism of hypertrophy remains unclear.
It is proposed that hypertrophy occurs due to chronic inflammation leading to accumulation of fibrous tissue (scarring) in the ligamentum flavum.
Inflammation-related gene expression is found in the ligamentum flavum. It might be possible to prevent the hypertrophy of ligamentum flavum with anti inflammatory drugs.
Reference : Ligamentum flavum hypertrophy due to accumulation of inflammation-related scar tissue; Sairyo K ; Spine (Phila Pa 1976). 2007 May 15;32(11):E340-7.