Friday 9 September 2011

Fahr's disease MRI

A 50 y o male with cognitive decline.  PTH and Thyroid hormones evaluation normal.
MRI Brain Axial T2*GRE, T2w and T1w images.
This MRI study of Brain shows:
Bilateral symmetric calcification in cerebral sub cortical white matter, caudate nuclei, lentiform nuclei, thalami and dentate nuclei of cerebellum is typical of Fahr's disease.
Calcification being dense seen as low signal intensities on T2 and T2 *GRE images and hyperintense on T1w images.

Fahr's disease

A rare neurodegenerative syndrome characterized by bilateral striopallidodentate calcinosis.

Endocrinal causes of intra cranial calcinosis or metastatic calcification are related to parathyroid and thyroid disorders which needs to be ruled out first.
When idiopathic, called as Fahr’s disease.

Calcium deposition usually begins in the third decade, clinically manifest two decades later with progressive neuropsychiatric disturbance, cognitive impairment and extra pyramidal movement disorders or in early adulthood with schizophrenic-like psychosis.

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