Sunday 12 February 2012

Huntington's Disease MRI

A 51 yo male under psychiatric treatment over several years. Relative complaining of his dementia. On neurological examination noticed Chorea. Family history was significant; father had a milder but similar illness.

Coronal MRI T1w image show:
Marked atrophy of caudate nuclei with ex vacuo dilatation of frontal horns. 
An associated diffuse cerebral cortical Atrophy.  

Imaging findings and history is consistent with Huntington's Disease.

Syn: Huntington Chorea.
An autosomal dominant neuro degenerative disorder with loss of GABAergic neurons of basal ganglia.
Clinically characterized by triad of Dementia, Choro athetosis and Psychosis.
Imaging wise diagnostic clue is caudate nuclei atrophy.
Age: Adult onset : 35 - 45years, Juvenile onset : < 20 years; M=F

2 comments:

Anonymous said...

Do we have any treatment for this Huntington's Desease..please provide me details........(tilakg007@yahoo.com)

Mathew Psychiatry said...

Great job for publishing such a nice article. Your article isn’t only useful but it is additionally really informative. we provide psychiatrist stamford ct at affordable prices. for more info visit our website.