Sunday 25 December 2016

Amyotrophic Lateral Sclerosis

        MC form of motor neuron disease.
        Progressive, neurodegenerative disorder.
        Upper (hyper reflexia, spasticity) and lower (fasciculation, atrophy) neuronal symptoms
       No autonomic, sensory, or cognitive involvement.

        Male predilection, onset in middle and late adult years.

Selective degeneration of somatic motor neurons of brain stem/spinal cord ( LMN), large pyramidal
neurons of motor cortex (upper motor neurons, UMN), eventual loss of corticospinal tract (CST) fibers.

Best diagnostic clue bilateral hyperintensities along CST extending from corona radiata to brain stem on

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