Cavernoma with Bleed

Non contrast CT study of brain shows right frontal Cavernoma with punctate calcifications. An adjacent Gliosis noted. 
MRI study of brain shows right frontal Cavernoma appears to be complicated with bleed which has resolved and is evident by Gliosis with low signal intensity hemosiderin staining on GRE. It is not uncommon for a Cavernoma patient to be asymptomatic, massive bleed in a Cavernoma is known but a rare complication. 


Cavernoma (Cavernous Malformation)
A benign vascular hamartoma, composed of closely packed immature blood vessels with intra lesional micro hemorrhages, without any neuronal tissue.
Best diagnostic clue is "Pop corn ball" like appearance with hemosiderin rim on T2w images.
Occur anywhere in brain. Rare in Spinal cord.
Vary in size from few mms to cms. Average size is between 1 to 5cm.
Usually single solitary, may be multiple, discrete lesions.
MRI is more sensitive and specific for detection of lesion.
Hyper dense on non contrast CT. Punctate Calcifications seen in ~ 50% cases. No to faint enhancement on post contrast.
On MRI lobulated appearance due to multiple locules which show variable signals, depending up on the blood degradation products. T1 bright locules attributed to Meth Hb - a sub acute stage blood degradation product. Low signal intensity hemosiderin rim on T2 images. Low signal intensity blooming on  T2*GRE images. No to faint enhancement on post contrast T1 images.
No to mild peri lesional odema.
No mass effect.

Clinical presentation:
Seizures 50%
Neuro deficit 25%
Asymptomatic 20%, detected as an incidnetal finding.
No intervention is a rule. But need follow up imaging as it may show progression or regression in size. Rarely show massive bleed.
Can affect any age group.
No gender preponderance.
Familial association in Hispanic Americans - Multiple Cavernoma Syndrome, carries higher risk for bleed and re bleed.

Similar cases:
cavernoma
cavernous-malformation
venous angioma with bleed

Cavernoma with Venous Angioma

A pontine Cavernoma (Cavernous Malformation) with an associated venous angioma has very typical imaging findings on MR as in this case.

MRI Brain Axial T1 and FLAIR, Axial post contrast CT. 

A pontine intra axial focal lesion with typical "popcorn ball" appearance, T1 bright locules which corresponds to Meth Hb – a sub acute stage blood degradation product. Low signal intensity hemosiderin rim on T2. No perilesional edema. No mass effect or volume loss. Blooming on GRE due to paramagnetic effect of blood degradation products. 

An associated venous angioma may be seen as in this case seen as enhancing serpentine hyperdensity on contrast enhanced CT. 

A venous angioma, also referred to as a "developmental venous anomaly" (DVA), a variation of normal. Usually seen as a little cluster or may seen as single prominent vein. May be seen isolated or in association with cavernoma as in thise case. Angioma on their own don't tend to cause any trouble, except very few (reported) exceptions of bleed, so should generally be left alone. When associated with cavernous malformations (cavernomas) tend to be troublesome, usually present with seizures.

Related post :
Venous Angioma with bleed : Venous Angioma a rare cause of intracerebral bleed.
Cavernoma-cavernous-malformation
Venous-angioma